تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Mandibular distraction osteogenesis: a rabbit model using a novel experimental design.
Mandibular distraction osteogenesis: a rabbit model using a novel experimental design.
 
لغة الوثيقة : الانجليزية 
المستخلص : PURPOSE: Distraction osteogenesis (DO) is a surgical procedure that targets bone regeneration and elongation, currently used in the treatment of many craniofacial deformities. The quest for optimization of DO clinical parameters has led to the development of a variety of animal models. Our study aims to establish a rabbit animal model of mandibular DO, in which the control osteotomy and distraction device are placed on the opposite hemimandible from the one being distracted, within the same animal host. Furthermore, we propose to histologically characterize the different stages or distraction and consolidation in the same animal model. MATERIALS AND METHODS: Twenty-five rabbits underwent mandibular osteotomies and bilateral placement of distraction devices. After a latency of 3 days, the distraction device was activated on one side of each animal at a rate of 0.5 mm/12 hours for 7 days, while the other side remained inactive (control). This was followed by a consolidation period of 14 days. Five animals per time-point were killed on days 3, 7, 10, 17, and 24. RESULTS: Gross tissue analysis showed a 7-mm callus formation at the distracted side and a well-healed osteotomy in the non-distracted side. Clinically, a unilateral Class III malocclusion occurred in the distracted side. Histology at each time-point shows new bone formation and orientation of the bony spicules along the axis of the mechanical strain. CONCLUSIONS: We have established and characterized an animal model of mandibular DO that outlines valid biologic controls and provides thorough monitoring of the DO process. 
ردمد : 0 
اسم الدورية : J Oral Maxillofac Surg 
المجلد : 63 
العدد : 5 
سنة النشر : 2005 هـ
2005 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Tuesday, February 9, 2010 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
ميساء السباعيAl-Sebaei, Misa باحث رئيسيدكتوراه 

الرجوع إلى صفحة الأبحاث