Document Details

Document Type : Thesis 
Document Title :
COHERENT MICROPOROUS TWISTED HYBRID NANO FIBERS FOR TISSUE ENGINEERING
الألياف النانوية الهجينة الملتوية صغيرة النفاذية المتماسكة لهندسة الأنسجة
 
Subject : Faculty of Engineering 
Document Language : Arabic 
Abstract : Nowadays tissue engineered scaffolds by electrospinning have become very attractive for vascular prostheses due to their ability to renovate the native tissue. The presented PhD thesis focuses on developing a new composite scaffold based on poly (lactic acid) (PLA), poly (butylene succinate) (PBS) and cellulose nano fibrils (CNF) by the process of electrospinning. The materials chosen and the developmental process can fulfill most of the essential requirements for vascular tissue engineering.The effect of electrospinning parameter and fiber collection method on fiber morphology of PLA/PBS scaffold was studied in order to optimize the electrospinning conditions for the scaffold fabrication. It was found that feed rate of 0.5 mL/h and needle-collector distance of 12 cm are required to generate smooth and uniform fibers in the smallest size with 6 wt% of polymer concentration at voltage of 20 kV. Then PLA/PBS scaffolds with different weight ratio were prepared using optimized electrospinning parameters and characterized for vascular tissue engineering. PLA/PBS scaffold with 50/50 ratio resulted in a uniform fibrous structure with desirable size dimension. The CNF is being introduced into PLA/PBS polymer matrix for the fabrication of composite scaffold by electrospinning. The developed composite scaffold consisting of 50% PLA, 48% PBS and 2% CNF results in the required and optimized properties needed in the vascular tissue engineering. Finally, the coherently blended, microporous walled and hollow fibrous scaffolds were developed from both PLA/PBS blends and CNF reinforced composites using coaxial electrospinning. Glycerol and mineral oil as core templates allowed hollow fiber formation but uniform pores dispersion on the wall occurred only when the mineral oil was used as a core template. Also the scaffold made by mineral oil template shows improved surface characteristics, enhanced cell adhesion and proliferation performance. 
Supervisor : Prof. Hamad Ali Al-Turaif 
Thesis Type : Master Thesis 
Publishing Year : 1441 AH
2019 AD 
Co-Supervisor : Dr. Usman Saeed 
Added Date : Tuesday, October 29, 2019 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
توريما يمايتي عبد اللهABUDULA, TUERDIMAIMAITI ResearcherDoctorate 

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